CD171 / L1CAM抗体

CD171 / L1CAM抗体产品信息免疫原 : Recombinant human CD171 protein ( Catalog#10140-H08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human CD171 ( rh CD171 ; Catalog#10140-H08H ; NP_000416.1 ; Met 1 - Glu 1120 ). Total IgG was purified by Protein A affinity chromatography
CD171 / L1CAM抗体背景综述
L1 cell adhesion molecule ( L1CAM ), also designated as CD171, is a transmembrane cell adhesion molecule belonging to the immunoglobulin superfamily, and has been implicated in a variety of processes integral to the development of the nervous system, including neuronal migration, neurite outgrowth, and axon fasciculation. It is primarily expressed on projection axons of the central nervous system and peripheral nervous system, as well as on a few nonneuronal cell types, such as Schwann cells and lymphocytes. The 1257 amino acid (aa) residue precursor protein contains an extracellular domain consisting of six Ig-like C2-type domains and five fibronectin-type I II domains and highly conserved transmembrane and cytoplasmic domains. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. In addition, L1CAM is also overexpressed in a variety of human carcinomas and is associated with bad prognosis.
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