Ficolin-1 / FCN1抗体

Ficolin-1 / FCN1抗体产品信息免疫原 : Recombinant human FCN1 Protein ( Catalog#10930-H08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human FCN1 ( rh FCN1 ; Catalog#10930-H08H ; NP_001994.2 ; Met 1 - Ala 326 ). Total IgG was purified by Protein A affinity chromatography.
Ficolin-1 / FCN1抗体背景综述
Ficolin ( collagen/fibrinogen domain containing ) 1, also known as FCN1 and M-ficolin, is a member of the ficolin family and is predominantly expressed in the peripheral blood leukocytes. The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three ficolins have been identified in humans: L-ficolin, H-ficolin and M-ficolin (also referred to as ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Dysfunction or abnormal expressions of ficolins may involved in the pathogenesis of human diseases including infectious and inflammatory diseases, autoimmune disease and clinical syndrome of preeclampsia.
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