PILRA抗体

PILRA抗体产品信息免疫原 : Recombinant mouse PILRA protein ( Catalog#50234-M08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse PILRA ( rM PILRA ; Catalog#50234-M08H ; NP_705730.1 ; Met 1 - Val 197 ). Total IgG was purified by Protein A affinity chromatography
PILRA抗体背景综述
Mouse paired immunoglobulin-like type 2 receptor alpha, also known as Inhibitory receptor PILR-alpha, Cell surface receptor FDF03, and PILRA, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. PILRA contains two copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. PTPN6 seems to bind predominantly to the first ITIM motif. PILRA is predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. PILRA is strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors and expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6 / SHP-1 and PTPN11 / SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
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