IL-1F6抗体

IL-1F6抗体产品信息免疫原 : Recombinant Mouse IL-1F6 protein (Catalog#50095-HNAE)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse IL-1F6 (rM IL-1F6; Catalog#50095-HNAE; Q9JLA2-1; Met 1-His 160). IL-1F6 specific IgG was purified by Mouse IL-1F6 affinity chromatography.
IL-1F6抗体 Background
Interleukin-1 family member 6, also known as IL-1F6, FIL1 epsilon, Interleukin-1 epsilon, IL-1 epsilon, IL1F6 and FIL1E, is a secreted protein which belongs to the IL-1 family. IL-1F6 is a new IL-1 family member. IL1F6 / FIL1E is expressed in immune system, fetal brain and adipose tissue and that IL-1F6 and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-1F6 inhibits PPARγ expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine.. IL1F6 / FIL1E, along with IL-36β / IL-1F8 and IL-36γ / IL-1F9, has been shown to act as an agonist by activating the pathway involving NF-κB and MAPK in an IL-1 Rrp2 dependent manner. IL1F6 / FIL1E may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.
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