VCAM-1 / CD106抗体

VCAM-1 / CD106抗体产品信息免疫原 : Recombinant Mouse VCAM-1 / CD106 protein (Catalog#50163-M08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse VCAM-1 / CD106 (rM VCAM-1 / CD106; Catalog#50163-M08H; NP_035823.3; Met 1-Glu 698). Total IgG was purified by Protein A affinity chromatography.
VCAM-1 / CD106抗体 Background
Vascular cell adhesion molecule 1 (VCAM1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM1 is expressed by a variety of cell types including activated endothelial cells, macrophages, dendritic cells, neurons, smooth muscle cells, fibroblasts, and oocytes. Up-regulation of VCAM1 in endothelial cells is induced by the cytokines IL-1β, IL-4, TNF-α and IFN-γ. VCAM1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4β7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. Accordingly, VCAM1 is thought to be involved in the extravasation or emigration of leukocytes in pathological immune responses and inflammation, and may plays a role in the development of atherosclerosis and rheumatoid arthritis.
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