Ephrin-A1 / EFNA1抗体

Ephrin-A1 / EFNA1抗体产品信息免疫原 : Recombinant Mouse Ephrin-A1 / EFNA1 protein (Catalog#50593-M08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse Ephrin-A1 / EFNA1 (rM Ephrin-A1 / EFNA1; Catalog#50593-M08H; NP_612182.1; Met 1-Ser 182). Total IgG was purified by Protein A affinity chromatography.
Ephrin-A1 / EFNA1抗体 Background
The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. Inmolecular biology, ephrins and Eph receptorsare components ofcell signalingpathways involved inanimaldevelopment, and implicated in some cancers. Eph receptors are classified asreceptor tyrosine kinases (RTKs), and form the largest sub-family of RTKs. Almost all Eph receptors are expressed during various well defined stages of development in assorted locations and concentrations. Mouse ephrin-A1, also known as B61, LERK-1, and EFL-1, is a member of the ephrin ligand family which binds members of the Eph receptor family. Ephrin-A1 has been shown to bind EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. The extracellular domains of human and mouse ephrin-A1 share 85% amino acid identity.
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