TGFBR3抗体

TGFBR3抗体产品信息免疫原 : Recombinant Mouse TGFBR3 protein (Catalog#50542-M08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse TGFBR3 (rM TGFBR3; Catalog#50542-M08H; NP_072075.2; Met 1-Arg 399). Total IgG was purified by Protein A affinity chromatography.
TGFBR3抗体 Background
Transforming growth factor beta receptor type 3, also known as TGF-beta receptor type 3, TGFR-3, Transforming growth factor beta receptor III, Betaglycan, TGF-beta receptor type III and TGFBR3, is a single-pass type I membrane protein. TGFBR3 / Betaglycan is known to be expressed in adult testis and ovary. TGFBR3 / Betaglycan was expressed within the fetal testis interstitium, predominantly by Leydig cells, but expression shifted inside the seminiferous cords at birth. TGFBR3 / Betaglycan was detected in both the somatic and germ cell lineages in the fetal and neonatal ovary. This differential expression pattern suggests divergent roles for this TGFBR3 in developing testis and ovary. TGFBR3 / Betaglycan is the TGF-beta component most commonly downregulated among localized human prostate cancer. TGFBR3 / Betaglycan downregulation is an important step in prostate tumorigenesis. TGFBR3 / Betaglycan is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFbeta) and inhibin, two members of the TGFbeta superfamily of growth factors that regulate many aspects of reproductive biology.
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