CCL17 / TARC抗体

CCL17 / TARC抗体产品信息免疫原 : Recombinant Human CCL17 / TARC protein (Catalog#10233-HNAB)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human CCL17 / TARC (rh CCL17 / TARC; Catalog#10233-HNAB; Q92583-1; Met 1-Ser 94). CCL17 / TARC specific IgG was purified by Human CCL17 / TARC affinity chromatography.
CCL17 / TARC抗体 Background
C-C motif chemokine 17, also known as CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CCL17 and SCYA17, is a secreted protein which belongs to the intercrine beta (chemokine CC) family. Chemokines are known to regulate the steady-state and inflammatory migration of cutaneous dendritic cells (DCs). The beta-chemokine CCL17, a ligand of CCR4, is inducibly expressed in a subset of DCs and is strongly up-regulated in atopic diseases. CCL17 / SCYA17 is constitutively expressed in the thymus and is produced by dendritic cells (DC), endothelial cells, keratinocytes (KC) and fibroblasts. CCL17 / SCYA17 is expressed at high levels in thymus and at low levels in the lung, colon and small intestine. CCL17 / SCYA17 is a chemotactic factor for T-lymphocytes but not monocytes or granulocytes. It may play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. CCL17 / SCYA17 binds to CCR4.Chemokine receptor CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune disease.
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