PRLR抗体

PRLR抗体产品信息免疫原 : Recombinant Rat PRLR protein (Catalog#80062-R08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Rat PRLR (rR PRLR; Catalog#80062-R08H; P05710-1; Met 1-Asp 229). Total IgG was purified by Protein A affinity chromatography.
PRLR抗体 Background
Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type Ⅰ cytokine receptor superfamily, and contains two fibronectin type-Ⅲ domains. PRLR is widely expressed in breast, placenta, kidney, liver and pancreas, and mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules invloved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. It has been shown that specific binding to PRLR can stimulate the breast cancer cells to grow and certain antagonists which bind but do not dimerize PRLR can inhibit the growth of breast cancer cells. Several isoforms have been described, and the soluble form are unable to transduce prolactin signaling.
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