CHK2 / CHEK2抗体

CHK2 / CHEK2抗体产品信息免疫原 : Recombinant Mouse CHK2 / CHEK2 protein (Catalog#50432-M20B)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse CHK2 / CHEK2 (rM CHK2 / CHEK2; Catalog#50432-M20B; Q9Z265; Mey1-Leu 546). CHK2 / CHEK2 specific IgG was purified by Mouse CHK2 / CHEK2 affinity chromatography.
CHK2 / CHEK2抗体 Background
Serine / threonine-protein kinase Chk2, also known as Cds1 and CHEK2, is a nucleusprotein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and CHK2 subfamily. CHEK2 regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. CHEK2 inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. CHEK2 may also play a role in meiosis. CHEK2 regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'. Defects in CHEK2 are associated with Li-Fraumeni syndrome 2 which is a highly penetrant familial cancer phenotype usually associated with inherited mutations in p53 / TP53. Defects in CHEK2 may be a cause of susceptibility to prostate cancer (PC) which is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
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