B2M / Beta-2-microglobulin抗体

B2M / Beta-2-microglobulin抗体产品信息免疫原 : Recombinant Mouse B2M / Beta-2-microglobulin protein (Catalog#50957-M08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse B2M / Beta-2-microglobulin (rM B2M / Beta-2-microglobulin; Catalog#50957-M08H; P01887; Met1-Met119). B2M / Beta-2-microglobulin specific IgG was purified by Mouse B2M / Beta-2-microglobulin affinity chromatography.
B2M / Beta-2-microglobulin抗体 Background
Beta-2-microglobulin, also known as B2M, is a secreted protein which belongs to the beta-2-microglobulin family. It contains one Ig-like C1-type (immunoglobulin-like) domain. Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals, including its association with major histocompatibility complex (MHC) Class I gene products. The latter molecules have been shown to affect reproduction in both mice and humans. B2M forms the small invariable light chain subunit of class I HLA antigens on the cell membrane of all nucleated cells. During the continuous turnover of the HLA molecules. B2M is shed from the cell membrane into blood. Lymphocytes are the main source of serum free B2M. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. In lymphatic malignancies serum B2M has significant prognostic value. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
B2M / Beta-2-microglobulin抗体相关产品如下：xy-2400R MDC1DNA损伤关卡蛋白1抗体
xy-2401R Nebulin伴肌动蛋白抗体
xy-1999R NDRG4抑癌基因NDRG4抗体
xy-2411R NKG2ANK细胞受体2A抗体
xy-2072R iNOS一氧化氮合成酶-2抗体（诱导型）
xy-1859R NGB脑红蛋白/神经血红蛋白/神经球蛋白抗体
xy-0069R Neurokinin A神经激肽A抗体
xy-3311R Phospho-Numb (Ser276)磷酸化膜相关蛋白Numb抗体
xy-3312R Phospho-NuMA (Ser395)磷酸化核有丝分裂器NuMA蛋白抗体
xy-3512R NuMA核有丝分裂器NuMA蛋白抗体
xy-3510R NUMB膜相关蛋白Numb抗体
xy-3507R NMDAR2A谷氨酸受体2A抗体
xy-3306R Phospho-NMDAR2B (Tyr1070)磷酸化谷氨酸受体2B抗体
xy-3307R NMDAR2B谷氨酸受体2B抗体
xy-3308R Phospho-Nucleophosmin (Ser4)磷酸化核仁磷酸蛋白抗体
xy-3309R Phospho-NPM (Thr95)磷酸化核仁磷酸蛋白抗体
xy-3310R Phospho-NPM (Thr199)磷酸化核仁磷酸蛋白抗体
xy-1156R IKB beta核因子κB抑制蛋白β抗体
xy-3305R Phospho-NMDAR2A (Tyr1325)磷酸化谷氨酸受体2A抗体
xy-1801R NPTN间质细胞衍化因子受体1抗体
xy-11918R Neuro D2神经细胞分化因子2抗体
xy-11678R Nuclear Pore Complex Proteins核孔复合体蛋白抗体
xy-8605R HSV 1神经毒性因子ICP34.5（人单纯疱疹病毒Ⅰ型）抗体
xy-11904R NOTUM背板胶质乙酰酯酶抗体
xy-11905R NPAS3神经细胞PAS结构域蛋白3抗体
xy-11913R NPDC1神经细胞增殖和分化调控蛋白1抗体
xy-11914R NRARPNOTCH调节锚蛋白抗体
xy-11915R NRSN1神经囊泡膜蛋白1抗体
xy-11916R Neugrin突触生长相关蛋白抗体
xy-8301R NDUFA9NDUFA9蛋白抗体
xy-8363R NIPA间变性淋巴瘤激酶核相互作用伴侣蛋白抗体
xy-8364R phospho-NIPA(Ser354)磷酸化间变性淋巴瘤激酶核相互作用伴侣蛋白抗体
xy-7764R NUSAP1核仁和纺锤体相关蛋白1抗体
xy-2054R Nkx2.5心脏特异性同源盒转录因子NKX2.5抗体
xy-2975R Noggin指(趾)关节粘连NOG蛋白抗体