Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse MFI2 / CD228 / melanotransferrin (rM MFI2 / CD228 / melanotransferrin; Catalog#50994-M08H; Q9R0R1; Met1-Gln708). Total IgG was purified by Protein A affinity chromatography.
MFI2 / CD228 / melanotransferrin抗体 Background
The melanotransferrin (MTf) molecule, also called CD228 or p97, has been widely described as a melanoma specific molecule. MTf is found at high levels in melanoma cells and previous studies have shown that MTf can bind Fe. MTf has a high level of sequence homology to transferrin (Tf) and lactoferrin, but is unusual because it predominantly occurs as a membrane bound, glycosylphosphatidylinositol (GPI) anchored molecule, but can also occur as a soluble form. The iron-binding properties of melanotransferrin, the tumour-associated antigen p97, have been investigated by many aspects and the results show that, in contrast to other transferrins, melanotransferrin binds only one Fe3+ ion per molecule. The binding properties of its N-terminal site are similar to other transferrins, but its C-terminal site does not bind iron at all. The differences can be related to specific amino acid changes in the C-terminal site. In clinical, The protein melanotransferrin (MTf) is associated with the brain lesions of Alzheimer's disease (AD) and is a potential marker of the disorder. Serum MTf is a candidate marker of AD, even in the early stage when clinical diagnosis is most uncertain.
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