TNFSF10 / TRAIL / APO-2L抗体

TNFSF10 / TRAIL / APO-2L抗体产品信息免疫原 : Recombinant Human TNFSF10 / TRAIL / APO-2L protein (Catalog#10409-H07E)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human TNFSF10 / TRAIL / APO-2L (rh TNFSF10 / TRAIL / APO-2L; Catalog#10409-H07E; NP_003801.1; Thr 95-Gly 281). TNFSF10 / TRAIL / APO-2L specific IgG was purified by Human TNFSF10 / TRAIL / APO-2L affinity chromatography.
TNFSF10 / TRAIL / APO-2L抗体 Background
TNF-related apoptosis-inducing ligand (TRAIL), also known as TNFSF10 or CD253, is a member of thetumor necrosis factor family. TRAIL functions as aligandwhich induces the process of cell death calledapoptosis. TRAIL shows homology to other members of thetumor necrosis factorsuperfamily. It is composed of 281 amino acids (aa) and has characteristics of a type IItransmembrane protein. The N-terminal cytoplasmic domain is not conserved across family members, however, the C-terminal extracellular domain is conserved and can be proteolytically cleaved from the cell surface. The identity between the canine and human TRAIL proteins is 81.3%. TRAIL binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. Preclinical studies showed that human TRAIL induced apoptosis of various tumor cell lines, whereas nontransformed normal cell lines were not affected.
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