BAFF / TNFSF13B抗体

BAFF / TNFSF13B抗体产品信息免疫原 : Recombinant Human BAFF / TNFSF13B protein (Catalog#10056-HNAE)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human BAFF / TNFSF13B (rh BAFF / TNFSF13B; Catalog#10056-HNAE; Q9Y275-1; Ala134-Leu285). Total IgG was purified by Protein A affinity chromatography.
BAFF / TNFSF13B抗体 Background
Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), also known as B cell-activating factor, CD257 and BAFF, is single-pass type I I membrane protein. It belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression of BAFF is found in placenta, heart, lung, fetal liver, thymus, and pancreas. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors are expressed mainly on mature B lymphocytes, and TACI binds with lowest affinity. TACI binds a protein similar to BAFFcalled A Proliferation Inducing Ligand (APRIL) with high. BCMA displays an intermediate binding phenotype and performs functions with either BAFF or APRIL to varying degrees. BAFF acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells.
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