DIM1 / TXNL4A抗体

DIM1 / TXNL4A抗体产品信息免疫原 : Recombinant Human DIM1 / TXNL4A protein (Catalog#12434-H07E)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human DIM1 / TXNL4A (rh DIM1 / TXNL4A; Catalog#12434-H07E; P83876; Met1-Tyr142). Total IgG was purified by Protein A affinity chromatography.
DIM1 / TXNL4A抗体 Background
DIM1, also known as TXNL4A, is a member of the Dim protein family. There are two members in the Dim protein family, DIM1and Dim2. They share a common thioredoxin-like fold. These two proteins were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. In spite of their biological and structural similarities, DIM1 and Dim2 proteins differ in many aspects. DIM1 bears distinctive structural motifs responsible for its interaction with other spliceosome components. Dim2 forms homodimers and contains specific domains required for its interactions with partners. This originality suggests that although both proteins are involved in pre-mRNA splicing, they are likely to be involved in different biological pathways. DIM1 interacts with HNRPF, HNRPH2, NEDD9/HEF1 and PQBP1/NPW38. It plays an essential role in pre-mRNA splicing.
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