CAMK4 / CaMKIV抗体

CAMK4 / CaMKIV抗体产品信息免疫原 : Recombinant Mouse CAMK4 / CaMKIV protein (Catalog#50838-M20B)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse CAMK4 / CaMKIV (rM CAMK4 / CaMKIV; Catalog#50838-M20B; P08414; Met1-Tyr469). Total IgG was purified by Protein A affinity chromatography.
CAMK4 / CaMKIV抗体 Background
Calcium/calmodulin-dependent protein kinase type IV, also known as CaMK IV, CaM kinase-GR and CAMK4, is cytoplasm and nucleus protein which belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and CaMK subfamily. CAMK4 is expressed in epithelial ovarian cancer tissue. CAMK4 is a calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. CAMK4 is a multifunctional serine/threonine protein kinase with limited tissue distribution, it has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. It may be involved in transcriptional regulation. CAMK4 may also be involved in regulation of microtubule dynamics. CAMK4 phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. It may play a role in the consolidation/retention of hippocampus-dependent long-term memory. CAMK4 is activated by Ca2+/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. It is phosphorylated by CAMKK1 or CAMKK2. CAMK4 interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca2+/calmodulin.
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