CD79B / B29抗体

CD79B / B29抗体产品信息免疫原 : Recombinant Rat CD79B / B29 protein (Catalog#80326-R08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Rat CD79B / B29 (rR CD79B / B29; Catalog#80326-R08H; O70153; Met1-Asp158). Total IgG was purified by Protein A affinity chromatography.
CD79B / B29抗体 Background
B-cell antigen receptor complex-associated protein beta chain, also known as B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b and B29, is a single-pass type I membrane protein which contains one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain. CD79b / B29 is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79b / B29 enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b / B29 are the cause of agammaglobulinemia type 6 (AGM6) which is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
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