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- Abcam
- 中国/美国/德国
- xy50736-RP01
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
E-selectin / ELAM-1 / CD62E抗体
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse E-selectin / ELAM-1 / CD62E (rM E-selectin / ELAM-1 / CD62E; Catalog#50736-M08H; Met1-Pro564). Total IgG was purified by Protein A affinity chromatography.
E-selectin / ELAM-1 / CD62E抗体 Background
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed at relatively high density on the surface of cultured endothelial cells that have been activated by proinflammatory cytokines, such as IL-1β, TNF-α, or bacterial endotoxin. E-Selectin/CD62e exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-Selectin/CD62e recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-Selectin/CD62e supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.
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文献和实验Clonality - X Chromosome Inactivation Assay
can utilize X chromosome inactivation (methylation) to determine the clonality status of a tumor or premalignant lesion in females. The technique is based on a methylation-sensitive restriction enzyme and analysis of a polymorphic locus on the X chromosome
X2 （Chi square method）也是一种好适度测验的方法，可以用来检验我们的实验结果和理论值有无差异，其公式为： X2 =Σ（d2 /e） e: 为预期值，即理论值； d：预期值和观察值或实验值之差。例如我们做了以下两组豌豆测交：查卡方表，一对性状，自由度N=2-1，X2 =10，P2 =2，0.05 X2 值的计算（紫花（Rr）×白花（rr
E- 选择素 (CD62E) E-选择素又称内皮细胞白细胞黏附分子-I(ELAM-1)，胞膜外区由1个C型凝集素样结构域、1个EGF样结构域和6个CCP组成，表达于炎症部位的内皮细胞。E-选择素通过其C型凝集素结构域同白细胞糖脂和糖蛋白上的唾液酸化路易糖(sLe)，以及唾液酸化的Lewis和相关的岩藻糖基化的N-乙酰乳糖胺结合。 E -选择素另一种糖蛋白配体是表达于髓样细胞的ESL-1蛋白(E-selectinligan&l
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