TNFa / TNFSF1A抗体

TNFa / TNFSF1A抗体产品信息免疫原 : Recombinant human TNFα protein ( Catalog#10602-HNAE )

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID : 9A7A5G9
Ig Type : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, E.coli-derived, recombinant human Tumor necrosis factor-alpha ( rhTNFα ; Catalog#10602-HNAE; Val 77- Leu 233 ; NP_000585.2 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
TNFa / TNFSF1A抗体 Background
Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF1A, is the prototypic cytokine of the the TNF superfamily. It is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF-α is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). Two receptors mediating the TNF-α function have been identified, the ubiquitous TNF RI from which most signaling are derived, and the hematopoietic cell-restricted TNF RII. TNF-α has been implicated in the pathogenesis of a variety of human diseases including autoimmune diseases, insulin resistance, and cancer.
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