CNTN2 / TAG-1抗体

CNTN2 / TAG-1抗体产品信息Immunogen: Human cell-derived rhCNTN2 ( Catalog#10457-H08H )

Clone ID: 8B9F4G1
Ig Type: Mouse IgG1
缓冲液: 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human CNTN2 (rhCNTN2; Catalog#10457-H08H; aa 1- 1012; NP_005067.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CNTN2 / TAG-1抗体 Background
Contactin-2 (CNTN2), also known as TAX1 (transiently expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, is a member of the contactin subfamily belonging to the immunoglobulin superfamily. CNTN2 is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI- specific phospholipase. CNTN2 is a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. CNTN2 plays an important role in cell adhesion, neurite outgrowth and axon guidance in the developing nervous system. CNTN2 mediated cell-cell contact is formed by cis-assisted trans-binding. Association of CNTN2 with Caspr2 (contactin -associated protein 2) is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. In addition, CNTN2 is also involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.
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