CD27 / TNFRSF7抗体

CD27 / TNFRSF7抗体产品信息免疫原 : Recombinant human CD27 / TNFRSF7 protein ( Catalog#10039-H03H )

Reagents : PE-conjugated rabbit monoclonal antibody
Clone ID : 023
抗体宿主 : Rabbit IgG
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CD27 (rh CD27; Catalog#10039-H03H; Met 1 - Ile 192; NP_001233.1) and conjugated with PE under optimum conditions, the unreacted PE was removed
CD27 / TNFRSF7抗体 Background
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, and during which, adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling processes. In addition, a proapoptotic protein named SIVA, is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.
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