IGFBP4 / IBP4抗体

IGFBP4 / IBP4抗体产品信息免疫原 : Recombinant human IGFBP4 protein ( Catalog#10967-H08H )

抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 5F7D12H3
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human IGFBP4 ( rh IGFBP4 ; Catalog#10967-H08H ; NP_001543.2 ; Met 1- Glu 258 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IGFBP4 / IBP4抗体背景综述
Insulin-like growth factor-binding proteins (IGFBPs) control bio-availability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified, and IGFBP4, the smallest IGFBP expressed by a wide range of cell types, exists in both non-glycosylated and N-glycosylated forms in all biological fluids. Structurally consisting of an IGFBP domain and a thyroglobulin type-I domain, IGFBP4 binds IGF-I and IGF-II with similar affinities as a transport protein and modulates their biological effects. Increasing evidences indicate that IGFBP4 inhibits IGF-induced cellular growth both in vitro and in vivo. As an important member of the IGF system, IGFBP4 is involved in a wide range of biological processes including reproductive physiology, bone formation, renal pathophysiology and carcinomas.
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