ASAM / ACAM抗体

ASAM / ACAM抗体产品信息免疫原 : Recombinant human ASAM protein ( Catalog#10794-H08H )

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 1H2B5D10

抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human ASAM extracellular domain ( rh ASAM ; Catalog#10794-H08H ; NP_079045.1 ; Met 1 - Met 233 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
ASAM / ACAM抗体背景综述
Adipocyte-specific adhesion molecule (ASAM), also known as ACAM and CLMP, is a type I transmembrane protein and a member of the CTX (cortical thymocyte marker in Xenopus) family within the immunoglobulin superfamily. The extracellular region of human ASAM contains two potential N-linked glycosylation sites, and two immunoglobulin domains, one variable (V-type) and one constant (C2-type), separated from each other by a J-segment. ASAM is highly expressed in the small intestine and placenta, and is found at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney, and lung, and appears in low levels in the liver and peripheral blood leukocytes as well. ASAM is a transmembrane component of tight junctions in epithelial cells that can mediate cell aggregation and regulate transepithelial resistance across polarized epithelial cells. Its expression is strongly correlated with white adipose tissue (WAT) mass of human and rodents with obesity. Human ASAM shares 94% and 93% aa sequence identity with rat and mouse ASAM, respectively.
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