IL-16抗体

IL-16抗体产品信息免疫原 : Recombinant Human IL-16 protein (Catalog#10944-H07E)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 04
抗体宿主 : Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-16 (rh IL-16; Catalog#10944-H07E; AAC12732.1; Pro 2-Ser 130). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL-16抗体 Background
Interleukin-16, also known as Lymphocyte chemoattractant factor, LCF and IL16, is a secreted, cytoplasm and nucleus protein which contains 4PDZ (DHR) domains. Interleukin-16 / IL16 was originally described as a factor that could attract activated T cells in humans, it was previously called lymphocyte chemoattractant factor (LCF). Since then, this interleukin has been shown to recruit and activate many other cells expressing the CD4 molecule, including monocytes, eosinophils, and dendritic cells. The structure of Interleukin-16 / IL16 was determined following its cloning in 1994. Interleukin-16 / IL16 is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. CD4 is the cell signaling receptor for mature IL-16. Interleukin-16 / IL16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. Interleukin-16 / IL16 is a cytokine that released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. The signaling process of Interleukin-16 / IL16 is mediated by CD4. It undergoes proteolytic processing, which is found to yield two functional proteins. Interleukin-16 / IL16 function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
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