TNFA / TNF-alpha抗体

TNFA / TNF-alpha抗体产品信息免疫原 : Recombinant Ferret TNFA / TNF-alpha protein (Catalog#60002-FNAE)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 11
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Ferret TNFA / TNF-alpha (rF TNFA / TNF-alpha; Catalog#60002-FNAE; A3FBF1; Val 77-Leu 233). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
TNFA / TNF-alpha抗体 Background
Tumor necrosis factor alpha (TNFa), also known as cachectin and TNFSF1A, is the prototypic cytokine of the the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNFa is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNFa is primarily produced as a 26 kDa type II transmembrane protein arranged in stable homotrimers, and a 55 kDa soluble trimeric form of TNFa is released via proteolytic cleavage by the metalloprotease TACE/ ADAM17. Two receptors mediating the TNFa function have been identified, the ubiquitous TNFRI from which most signaling are derived, and the hematopoietic cell-restricted TNFRII. Upon the TNFa trimers binding, TNF receptors also form trimers, undergo a conformational change, and enable the adaptor protein TRADD to bind to the death domain, and thus initiates the signal pathways such as the NF-kB, Jak/STAT, and the MAPK pathways, as well as the death signaling. As a major mediator of apoptosis, inflammation and immunity, TNFa has been implicated in the pathogenesis of a variety of diseases including autoimmune diseases, insulin resistance, and cancer.
TNFA / TNF-alpha抗体相关产品如下：xym-0388M IFN gamma(F2E4)γ-干扰素/γ-IFN单克隆抗体
xy-0481R IFN gamma干扰素-γ/IFN-γ抗体
xy-0480R IFN gamma干扰素-γ/IFN-γ抗体
xy-0227R IGF1R胰岛素样生长因子I受体抗体
xy-0680R IGF1R胰岛素样生长因子1受体抗体
xy-1108R IGFBP2胰岛素样生长因子结合蛋白2抗体
xy-0406R IGFBP5胰岛素样生长因子结合蛋白5抗体
xy-0014R IGF 1胰岛素样生长因子1抗体
xy-0015R IGF II胰岛素样生长因子-II抗体
xy-0698R IL-10白细胞介素10抗体
xy-0560R IL-13白介素13抗体
xy-1183R IL-17白介素-17抗体
xy-0529R IL-18白细胞介素-18/干扰素γ诱导因子抗体
xy-0445R IL1RAPL1白介素1受体相关蛋白样1前体蛋白抗体
xy-0812R IL-1 Beta白介素1β/IL-1β抗体
xy-1191R IL-2白介素2抗体（大、小鼠）
xym-0389M IL-2(H2E4)白细胞介素-2单克隆抗体
xy-1193R IL-23白介素-23抗体
xy-0581R IL-4白介素4抗体
xy-0781R IL-6白介素6
xy-0782R IL-6白介素6抗体
xy-0379R IL-6白介素6抗体
xy-1032R Inhibin Alpha抑制素A/Inhibin α抗体
xy-1674R ILTV glycoprotein E鸡传染性喉气管炎病毒糖蛋白E抗体
xy-0898R intestinal FABP小肠型脂肪酸结合蛋白抗体
xy-1540R IL-7Ra白细胞介素-7受体a抗体
xy-2093R Integrin alpha 3整合素α3抗体
xy-2094R Integrin beta 5整合素β5抗体
xy-2095R Integrin alpha 1整合素α1抗体
xy-1959R IL2 Receptor beta白介素2受体β链抗体 IL-2Rβ
xy-0536R Interferon alpha 2b干扰素α2b抗体
xy-2471R ICOS ligand诱导协同刺激分子配体CD275抗体
xy-10050R IBDV鸡传染性法氏囊病病毒抗体
xy-2140R IL-17白介素-17抗体
xy-5924R IMPDH25'肌苷磷酸脱氢酶2抗体