C1QBP / HABP1抗体

C1QBP / HABP1抗体产品信息免疫原 : Recombinant Human C1QBP / HABP1 protein (Catalog#11874-H08E)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 04
抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human C1QBP / HABP1 (rh C1QBP / HABP1; Catalog#11874-H08E; NP_001203.1; His 75-Gln 282). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
C1QBP / HABP1抗体 Background
Complement component 1 Q subcomponent-binding protein, mitochondrial, also known as GC1q-R protein, Glycoprotein gC1qBP, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, p33 and C1QBP, is a nucleus protein which belongs to theMAM33 family. Human C1QBP (p33, p32, GC1q-R, TAP) is a ubiquitously expressed, multiligand-binding, multicompartmental cellular protein involved in various ligand-mediated cellular responses. C1QBP is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. Although expressed on the surface of cells, an intriguing feature of the membrane-associated form of C1QBP is that its translated amino acid sequence does not predict the presence of either a sequence motif compatible with a transmembrane segment or a consensus site for a glycosylphosphatidylinositol anchor. Moreover, the N-terminal sequence of the pre-pro-protein C1QBP contains a motif that targets the molecule to the mitochondria and as such was deemed unlikely to be expressed on the surface. C1QBP also interacts with HIV-1 Tat.
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