FGF10抗体

FGF10抗体产品信息免疫原 : Recombinant Human FGF10 protein (Catalog#10573-HNAE)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 07
Ig Type : Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FGF10 (rh FGF10; Catalog#10573-HNAE; NP_004456.1; Gln 38-Ser 208). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
FGF10抗体 Background
The fibroblast growth factors (FGFs) are a growing family of heparin-binding growth factors that that regulate a variety of physiological processes in both developing and adult organism. The secreted human FGF10 exists most abundantly in the embyro and adult lung, and is most closely related to FGF7. It signaling through FGF receptor 2 (FGFR2) controls survival, proliferation, and differentiation of distal-alveolar epithelial progenitor cells during lung development. FGF10 overexpression during both the inflammatory and fibrotic phases results in a greatly reduced extent of lung fibrosis, suggesting that FGF10 may be useful as a novel approach to the treatment of pulmonary fibrosis. Additionally, FGF10 is also proposed as a growth factor active involved in the process of wound healing and limb bud formation. Human FGF10 shares approximately 92% and 95% amino acid sequence identity with mouse and rat FGF10, respectively.
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