14-3-3 beta / YWHAB抗体

14-3-3 beta / YWHAB抗体

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  • 询价
  • Abcam
  • 中国/美国/德国
  • xy10843-MM03-F
  • 2025年07月14日
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    • 详细信息
    • 技术资料
    • 保存条件

      常温,避光

    • 克隆性

      单克隆

    • 抗体名

      14-3-3 beta / YWHAB抗体

    14-3-3 beta / YWHAB抗体产品信息免疫原 : Recombinant Human 14-3-3 beta / YWHAB protein (Catalog#10843-H09E)

    Reagents : FITC-conjugated mouse monoclonal antibody
    Clone ID : 03
    抗体宿主 : Mouse IgG2b
    Concentration : 10 μl/Test, 0.1 mg/ml
    缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
    制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human 14-3-3 beta / YWHAB (rh 14-3-3 beta / YWHAB; Catalog#10843-H09E; NP_003395.1; Met 1-Asn 246) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
    14-3-3 beta / YWHAB抗体 Background
    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB), also known as14-3-3 protein beta / alpha and protein kinase C inhibitor protein 1 (KCIP1), is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAB has been repoted to interact with SSH1,TORC2/CRTC2, ABL1, ROR2, GAB2, and thus is invloved in the related processes, such as apoptosis. Inaddition, YWHAB may serve as a negative regulator of osteogenesis.
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