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- xy10902-MM03
- 2025年07月15日
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- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
CCNE1 / Cyclin-E1抗体
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 03
抗体宿主 :
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CCNE1 / Cyclin-E1 (rh CCNE1 / Cyclin-E1; Catalog#10902-H07B; NP_001229.1; Met1-Ala410). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CCNE1 / Cyclin-E1抗体 Background
G1/S-specific cyclin-E1, also known as CCNE1 and CCNE, is a nucleus protein which belongs to thecyclin family and Cyclin E subfamily. CCNE1 is highly expressed in testis and placenta, and is expressed at low levels in bronchial epithelial cells. As a positive regulator of the cell cycle, CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. In numerous human tumors, CCNE1 expression is frequently dysregulated, while the mechanism leading to its dysregulation remains incompletely defined. CCNE1 interacts with a member of the CDK2 / CDK protein kinases to form a serine / threonine kinase holoenzyme complex, including CDK2, CABLES1 and CCNA1, and the cyclin subunit of CCNE1 imparts substrate specificity to the complex. It interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. CCNE1 is also a potential therapeutic target in ovarian cancer. CCNE1-targeted therapy may benefit ovarian cancer patients with CCNE1 amplification.
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文献和实验雌体有相同的性染色体时，此性染色体称为X染色体。在性别决定上， XX为雌， XY（或 XO）为雄。过去 C． E． Mcclung（ 1901）在昆虫中曾将此命名为副染色体（ accessory chromosome）。通过多倍体、异倍体实验证明，在果蝇的 X染色体上可能具有导致雌性性征发育的基因，但也有可能是 X染色体作为整体来决定雌性性别；而由常染色体决定雄性性别。在包括人类在内的高等哺乳类中，雌性个体细胞核中的 2条 X染色体，其中有一条异常凝缩，遗传上表现为无活性。
3 篇 Nature 连发，解决世纪难题，周期蛋白的毁灭调控蕴含癌症患者的新生
在 cyclin D 上，被泛素化标记的 cyclin D 将会被蛋白酶体降解。此外研究还发现，AMBRA1 缺失会导致 cyclin D 和 MYC 蛋白水平升高。cyclin D 与 CDK4/6 结合，使 RB1 蛋白磷酸化。磷酸化 RB1 释放 E2F 转录因子来驱动细胞周期进程所需基因的表达。在 AMBRA1 缺失的细胞中，cyclin D 也能与 CDK2 激酶形成复合物，使癌细胞能够抵抗 CDK4/6 抑制剂的治疗。高水平的 cyclin D 会促进细胞增殖，从而导致 DNA 损伤、复制应激
Assays for Cyclin-Dependent Kinase Inhibitors
of the Retinoblastoma gene product (Rb) by CDK4 and/or CDK6 (G1/S checkpoint), leading to the release of bound E2F from Rb and allowing the transcription of genes by “free E2F” necessary for S phase progression. During late G1 phase, CDK2/cyclin E complex phosphorylates
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