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- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
vWF / von Willebrand factor抗体
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 111
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, CHO cell-derived, recombinant human von Willebrand factor ( rh vWF; Catalog#10973-H08C; Met 1- Lys 2813; NP_000543.2 )
vWF / von Willebrand factor抗体 Background
Von Willebrand factor (vWF) is a blood glycoprotein which is involved in a large number of diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome. Its primary function is binding to other proteins, particularly Factor VIII and it is important in platelet adhesion to wound sites. vWF appears to play a major role in blood coagulation. Its deficiency or dysfunction leads to a bleeding tendency, which is most apparent in tissues having high blood flow shear in narrow vessels. It appears that vWF uncoils under these circumstances, decelerating passing platelets. Hereditary or acquired defects of vWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing menorrhagia, and gastrointestinal bleeding.
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文献和实验Multimeric Analysis of von Willebrand Factor
Von Willebrand Factor (vWF) in normal plasma is composed of a series of high molecular multimers, ranging in size from 8�105 to over 15�106 Daltons (1 ). The multimeric structure of vWF was first investigated by two-dimensional crossed
Screening for Candidate Mutations Causing von Willebrands Disease (vWD)
von Willebrand factor (vWF) is a large, complex glycoprotein that exists in plasma and platelets, and is synthesized by megakaryocytes and endothelial cells. vWF plays an essential role in hemostasis in at least two ways. It is involved
-Duistermaat j.j,et.al. Familial clustering of factor Ⅷ and von Willebrand Factor levels , Thromb Haemost 1998,79:323-7 2.O , Donnell J,Mumford A.D,Manning R,A,Elevation of F Ⅷ :C in venous thrombembolism is persistent and independent of the Axute
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