Dkk3抗体

Dkk3抗体产品信息免疫原 : Recombinant Mouse Dkk3 protein (Catalog#50247-M08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 019
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse DKK3 (rM DKK3; Catalog#50247-M08H; NP_056629.1; Met 1-Ile 349).
Dkk3抗体 Background
DKK3, also known as REIC (Reduced Expansion in Immortalized Cells), is a member of the dickkopf-related family consisting of four members which have distinct patterns of expression in adult and embryonic tissues. DKK3 is a secreted protein with two cysteine-rich domains separated by a linker region, and has a wide range of effects on tissue development and morphogenesis through its interactions with the Wnt signaling pathway. Mouse DKK3 is highest expressed in brain, eye and heart. The expression of this gene is down-regulated in human immortalized cells and a variety of tumors, such as hepatoma, lung carcinomas and malignant melanoma. Meanwhile, overexpression of DKK3 results in tumor cell line-specific growth inhibition and apoptosis. Accordingly, DKK3 may function as a suppressor gene of tumor growth and be regarded as a promising potential therapeutic target.
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