Carbonic Anhydrase XIV / CA14抗

Carbonic Anhydrase XIV / CA14抗体产品信息免疫原 : Recombinant Mouse Carbonic Anhydrase XIV / CA14 Protein (Catalog#50013-M08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 033
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse Carbonic Anhydrase XIV / CA14 ( rM Carbonic Anhydrase XIV / CA14; Catalog#50013-M08H; NP_035927.1; Met 1 - Met 290)
Carbonic Anhydrase XIV / CA14抗体 Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form HCO3- and protons. Since discovered in 1933, fifteen CA isoforms have been reported sofar. CA I, CA II, CA III, CA VII, and CA XIII are cytosolic enzymes, whereas CA IV, CA IX, CA XII, CA XIV, and CA XV are membrane-associated isoforms. They have different patterns of tissue-specific expression and play different physiologic roles. CA XIV is a polypeptide consisting of an extracellular N-terminal catalytic domain, a membrane-spanning segment and a short intracellular C-terminal segment with several potential phosphorylation sites. CA14 is highly expressed in all parts of the central nervous system (CNS) with lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder, and skeletal muscle.
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