Coagulation Factor III / Tissu

Coagulation Factor III / Tissue Factor / CD142 / F3抗体产品信息免疫原 : Recombinant Mouse Coagulation Factor III / Tissue Factor / CD142 / F3 Protein (Catalog#50413-M08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 034
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse Coagulation Factor III / Tissue Factor / CD142 / F3 ( rM Coagulation Factor III / Tissue Factor / CD142 / F3; Catalog#50413-M08H; NP_034301.3; Met 1 - Glu 251)
Coagulation Factor III / Tissue Factor / CD142 / F3抗体 Background
Tissue factor, also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Because of its essential role in hemostasis, Tissue factor plays a role in pathology associated with hemostasis, triggering the coagulation system in many thrombotic diseases and the coagulopathies associated with sepsis and other forms of disseminated intravascular coagulation. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes.
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