- 询价
- Abcam
- 中国/美国/德国
- xy11342-R201
- 2025年07月10日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 克隆性：
单克隆
- 抗体名：
ORP150 / HYOU1 / HSP12A抗体
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 201
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human ORP150 / HYOU1 / HSP12A (rh ORP150 / HYOU1 / HSP12A; Catalog#11342-H08H; NP_001124463.1; Met 695-Leu 994).
ORP150 / HYOU1 / HSP12A抗体 Background
Hypoxia up-regulated protein 1, also known as 150 kDa oxygen-regulated protein, 170 kDa glucose-regulated protein, ORP-150, GRP-170 and HYOU1, is a member of theheat shock protein 70 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1 (ORP150), HSPC1 (HSP86), HSPA5 (Bip), HSPD1 (HSP60), and several isoforms of the two testis-specific HSP70 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. It is highly expressed in liver and pancreas. HYOU1 is also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. HYOU1 has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. It may play a role as a molecular chaperone and participate in protein folding. Suppression of HYOU1 is associated with accelerated apoptosis. It is suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness.
ORP150 / HYOU1 / HSP12A抗体相关产品如下：xy-1535R Alkaline Phosphatase碱性磷酸酶抗体
xy-2114R AU1 tagAU1 tag标签抗体
xy-0322R AEBP1脂肪细胞增强结合蛋白1
xy-0115M AKT1蛋白激酶B
xy-0115R AKT1蛋白激酶B
xy-0537R ANGL2血管生成素样蛋白2抗体
xy-1087R Angiopoietin 4血管生成素3/血管生成素4抗体
xy-1171R Annexin I膜粘连蛋白 I抗体
xy-0576R Annexin A2膜粘连蛋白 Ⅱ抗体
xy-0517R ATF1活化转录因子1抗体
xy-0634R Aquaporin 4 水通道蛋白4抗体
xy-0518R ATF2活化复制因子2抗体
xy-1116R AMPK beta 1腺苷单磷酸活化蛋白激酶β1抗体
xy-0057R Amylin糖尿病相关肽/胰岛淀粉样肽抗体
xy-0587R Angiotensin II血管紧张素Ⅱ抗体
xy-0438R AT2R血管紧张素Ⅱ受体1抗体
xy-0800R Angiopoietin-1血管生成素-1抗体
xy-0398R Annexin V膜粘连蛋白5抗体
xy-0450R Annexin V重组膜粘连蛋白5抗体
xy-1228R alpha Adaptin衔接蛋白α-Adaptin抗体
xy-0058R APAF1(CT)凋亡蛋白活性因子-1抗体（C端）
xy-0059R APAF1(NT)凋亡蛋白活性因子-1抗体（N端）
xy-0662R ABCG2三磷酸腺苷结合转运蛋白G超家族成员2抗体
xy-0167R APOE载脂蛋白E抗体
xy-0112M Amyloid Precursor Protein淀粉样肽前体蛋白抗体
xy-0261R Aquaporin 2水通道蛋白-2抗体
xy-0045M AGT血管紧张素原抗体
xy-0118R Androgen receptor雄激素受体抗体
xy-2438R AVEN细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂)
xy-2439R Axin1轴蛋白1抗体
xy-4011R ATG9B自噬相关蛋白9B抗体
xy-4012R Apg12自噬相关蛋白12抗体
xy-3864R ATG13自噬相关蛋白13抗体
xy-4013R ATG3自噬相关蛋白3抗体
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验5. Electorophoresis with 100-130 V in 0.25X TBE buffer for 3 hours. You may use 18 cm-height gel system and stop running after dye front comes to 12 cm point from the top. When a gel was run with 130 V, the current was less than 20 mA. You could run a gel
、双甲基化或三甲基化有关。组蛋白修饰最基本的作用是调控基因表达。例如组蛋白甲基化多导致基因沉默，去甲基化则相反；乙酰化一般是转录激活，去乙酰化则相反。当然，也可在此基础上产生复杂的生物学效应。例如组蛋白去乙酰化酶 HDAC 可影响免疫系统；H3K4me3、H3K9me2 能够调控记忆的形成, 而且 H3K 甲基化与 X 染色体失活、基因组印记和异染色质形成有关；H3 乙酰化通过多种机制调控以来 ATP 的染色质重塑 [12]，并参与炎症反应；H2A、H2B 泛素化则与 DNA 损害反应有关；而 H3
删除突变的drs基因分析揭示，C末端区以及3个一致重复的N末端区都出现凋亡。Caspase-12、Caspase –9以及Caspase-3都继续被drs激活，Caspase--3,和Caspase-9的抑制剂都抑制drs引起的凋亡。在凋亡过程中没有看到因drs引起线粒体细胞色素C释放到细胞质去，这表明线粒体途径不是drs介导的凋亡，而且，研究人员发现，Drs蛋白能与定位在内质网的凋亡蛋白ASY/Nogo-B/RTN-x(S)结合，并且这些基因共同表达增加了凋亡的效果。这项研究结果提示，由ASY
技术资料暂无技术资料 索取技术资料
