CSF1R / MCSF Receptor / CD115抗

CSF1R / MCSF Receptor / CD115抗体产品信息免疫原 : Recombinant Mouse CSF1R / MCSF Receptor / CD115 protein (Catalog#50059-M08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 220
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CSF1R / MCSF Receptor / CD115 (rM CSF1R / MCSF Receptor / CD115; Catalog#50059-M08H; NP_001032948.2; Met 1-Ser 511).
CSF1R / MCSF Receptor / CD115抗体 Background
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1, a cytokine involved in the proliferation, differentiation, and activation of macrophages. As a member of the typeIII subfamily of receptor tyrosine kinases (RTKs), M-CSF receptor is expressed mainly on cells of monocyte/macrophage lineage, and consists of an extracellular ligand-binding domain and a cytoplasmic protein tyrosine kinase (PTK) domain joined through a single transmembrane helix. Ligand binding induces the M-CSF receptor homodimerization, and leads to transphosphorylation of specific tyrosine and the subsequent signal transduction. This activated receptor exerts actions on multiple intracellular effectors which determine the magnitude and specificity of the biological responses, and thus mediates most if not all of the biological effects of the CSF1 cytokine, including cell growth, survival, differentiation and chemotaxis. Mutations of this gene have been associated with a predisposition to myeloid malignancy.
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