Leptin Receptor / CD295 / LEPR

Leptin Receptor / CD295 / LEPR抗体产品信息免疫原 : Recombinant Human Leptin Receptor / CD295 / LEPR protein (Catalog#10322-H08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 003
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human Leptin Receptor / CD295 / LEPR (rh Leptin Receptor / CD295 / LEPR; Catalog#10322-H08H; NP_002294.2; Met1-Asp839).
Leptin Receptor / CD295 / LEPR抗体 Background
Leptin receptor (LEPR), also known as OB-R and B219, is a single-transmembrane-domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is expressed at high levels in hematopoietic stem cells, lymphohematopoietic cell lines, as well as adult reproductive organs. Several isoforms of LEPR have been identified, and LEPR structurally contains two hemopoietin receptor domains, a fibronectin type III domain and a WSXWS domain within the extracellular region. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
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