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- 详细信息
- 技术资料
- 保存条件:
常温,避光
- 克隆性:
单克隆
- 抗体名:
Influenza A H5N1 HA抗体
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant Influenza A virus H5N1 ( Avian Flu ) Hemagglutinin extracellular domain. Total IgG was purified by Protein A affinity chromatography.
Influenza A H5N1 HA抗体背景综述
Influenza (flu) is a respiratory infection in mammals and birds. This virus is divided into three main types (A, B and C). Influenza A is found in a wide variety of bird and mammal species. Influenza B is largely confined to humans and is an important cause of morbidity. Influenza C infects humans, dogs and pigs, sometimes causing both severe illness and local epidemics. Influenza A is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA). The notation HhNn is used to refer to the subtype comprising the hth discovered HA protein and the nth discovered NA protein. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. Subtypes are further divided into strains. Each genetically distinct virus isolate is usually considered to be a separate strain.
Influenza A virus subtype H5N1, also known as "bird flu", A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. H5N1 is easily transmissible between birds facilitating a potential global spread of H5N1. It is mainly spread by domestic poultry, both through the movements of infected birds and poultry products and through the use of infected poultry manure as fertilizer or feed. Humans with H5N1 have typically caught it from chickens, which were in turn infected by other poultry or waterfowl. Influenza H5N1 (A/Anhui/1/2005) virus was isolated from a specimen of tracheal aspirate. The whole genome sequencing indicated that all segments were of avian origin. The hemagglutinin receptor binding site was similar to those of other avian H5N1 viruses, and a polybasic amino acid cleavage site was present.
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