RAGE / AGER抗体

RAGE / AGER抗体产品信息免疫原 : Recombinant Mouse RAGE / AGER protein (Catalog#50489-M08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 005
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse RAGE / AGER (rM RAGE / AGER; Catalog#50489-M08H; NP_031451.2; Met1-Ala342).
RAGE / AGER抗体 Background
Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, is a single-pass type I membrane protein. AGER / RAGE contains twoIg-like C2-type (immunoglobulin-like) domains and oneIg-like V-type (immunoglobulin-like) domain. AGER / RAGE mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. AGER / RAGE acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE / RAGE signaling plays an important role in regulating the production / expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction between AGER / RAGE and S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction between AGER / RAGE and S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. AGER / RAGE contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons.
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