IL-1 beta / IL1B抗体

IL-1 beta / IL1B抗体产品信息免疫原 : Recombinant Mouse IL-1 beta / IL1B protein (Catalog#50101-MNAE)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 001

抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1 beta / IL1B (rM IL-1 beta / IL1B; Catalog#50101-MNAE; P10749; Val118-Ser269).
IL-1 beta / IL1B抗体 Background
Interleukin-1 beta, also known as IL-1 beta, and IL1B, is a secreted protein which belongs to the IL-1 family. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 / Interleukin-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 beta / IL1B is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1 / ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1 beta / IL1B is a potent pro-inflammatory cytokine. It is directly up-regulated by radiation and is known to regulate other inflammation-related molecules, such as the matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs). IL-1 beta / IL1B plays a critical role in radiation-induced fibrosis and the increased MMPs fail to block the IL1-related collagen accumulation. The induction of cyclooxygenase-2 (PTGS2 / COX2) by IL-1 beta / IL1B in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.
IL-1 beta / IL1B抗体相关产品如下：xy-5292R phospho-DAXX (Ser517)磷酸化Fas相关死亡结构域蛋白抗体
xy-5293R phospho-DAXX (Ser671)磷酸化Fas相关死亡结构域蛋白抗体
xy-5294R phospho-Dnmt1(Ser154)磷酸化DNA甲基转移酶1抗体
xy-5295R phospho-Dnmt1(Ser732)磷酸化DNA甲基转移酶1抗体
xy-5296R phospho-Dnmt1(Tyr399)磷酸化DNA甲基转移酶1抗体
xy-5057R DHCR77脱氢胆固醇还原酶抗体
xy-8173R Dbx2大脑发育同源蛋白2抗体
xy-4057R DEGS1退行性精母细胞同源物1抗体
xy-7720R DSCC1DSCC1蛋白抗体
xy-4962R DcR2诱捕受体2抗体
xy-13009R DMAP1DNA甲基转移酶相关蛋白1抗体
xy-13010R DMC1减数分裂同源蛋白DMC1抗体
xy-13011R DNA Ligase IIIDNA连接酶3抗体
xy-13012R phospho-DNA PKcs (Thr2638)磷酸化DNA依赖性蛋白激酶抗体
xy-13013R phospho-DNA PKcs (Thr2647)磷酸化DNA依赖性蛋白激酶抗体
xy-13014R DNA polymerase delta p50DNA聚合酶δ2/DNA pol δ 2抗体
xy-13015R DNA Polymerase delta, catalytic subunitDNA聚合酶δ催化亚单位/DNA pol δ cat抗体
xy-13016R DNA polymerase etaDNA聚合酶η抗体
xy-13017R DNA Polymerase gammaDNA聚合酶γ/DNA pol γ抗体
xy-13018R DNA Polymerase iotaDNA聚合酶ι/DNA pol ι抗体
xy-13019R DNA Polymerase Kappa/POLKDNA聚合酶κ/DNA pol κ抗体
xy-13020R DNA Polymerase lambdaDNA聚合酶λ/DNA pol λ抗体
xy-13021R DNA polymerase muDNA聚合酶μ/DNA pol μ抗体
xy-13023R DNAJA2细胞周期蛋白3抗体
xy-13024R DNAJC9DNAJC9蛋白抗体
xy-13025R Dnmt2DNA甲基转移酶2抗体
xy-13026R Dnmt3LDNA甲基转移酶3L抗体
xy-13028R DPP10二肽基肽酶10抗体
xy-13029R DPP3二肽氨基肽酶3抗体
xy-13030R DREFDNA复制相关元件结合因子抗体
xy-13031R DRIL1B淋巴细胞转录调节相关蛋白DRIL1抗体
xy-13032R DRIP130转录共激活因子130抗体
xy-13033R Drosha核糖核酸酶3/Drosha抗体