CD112 / Nectin-2抗体

CD112 / Nectin-2抗体产品信息
免疫原 : Recombinant Human CD112 / Nectin-2 protein (Catalog#10005-H08H)
Reagents : PE-conjugated rabbit monoclonal antibody
Clone ID : 005
抗体宿主 : Rabbit IgG
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human CD112 / Nectin-2 (rh CD112 / Nectin-2; Catalog#10005-H08H; NP_002847.1; Met1-Leu360) and conjugated with PE under optimum conditions, the unreacted PE was removed.
CD112 / Nectin-2抗体 Background
CD112, also known as poliovirus receptor related 2 (PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily, and structurally comprises two Ig-like C2-type domains and one Ig-like V-type domain in the extracellular region. As a homophilic adhesion molecule, CD112 is widely expressed in human tissues including hematopoietic cells and mediates intercellular junctions of adjacent cells. This protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
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