LAMP-1 / CD107a抗体

LAMP-1 / CD107a抗体产品信息
免疫原 : Recombinant Human LAMP-1 / CD107a protein (Catalog#11215-H08H)
Reagents : PE-conjugated rabbit monoclonal antibody
Clone ID : 107
抗体宿主 : Rabbit IgG
Concentration : 5 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human LAMP-1 / CD107a (rh LAMP-1 / CD107a; Catalog#11215-H08H; NP_005552.3; Met1-Met382) and conjugated with PE under optimum conditions, the unreacted PE was removed.
LAMP-1 / CD107a抗体 Background
Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to theLAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
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