Purified 抗小鼠 CD107a (LAMP-1) 抗

Purified anti-mouse CD107a (LAMP-1) Antibody详细如下：

Description ：CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation,CD107a is transferred to the cell membrane surface of activated platelets, activatedlymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107ahas been suggested to play a role in the protection of lysosomal membrane from lysosomalhydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediatesautoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surfaceexpression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

Verified Reactivity ：Mouse

Antibody Type ：Monoclonal

Host Species ：Rat

Immunogen ：This monoclonal antibody was raised against NIH/3T3 mouse embryonic fibroblast tissue culturecell membranes. It has been mapped to the N-terminus of LAMP-1.

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation ：The antibody was purified by affinity chromatography.

Concentration ：0.5 mg/ml

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.

Application ：FC - Quality tested、WB - Verified、ICC, IP - Reported in the literature, not verified in house

Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per millioncells in 100 µl volume. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg perml. It is recommended that the reagent be titrated for optimal performance for each application.