PHPT1 Antibody

PHPT1 Antibody Product Information
Immunogen :
Recombinant Human PHPT1 protein (Catalog#12473-H07E)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID :
007
Ig Type :
Rabbit IgG
Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :
This antibody was obtained from a rabbit immunized with purif
PHPT1 Antibody Background
PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to thejanus family. PHPT1 / PHP14 is expressed abundantly in heart and skeletal muscle. Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. Protein histidine phosphorylation exists widely in vertebrates, and it plays important roles in signal transduction and other cellular functions. Protein histidine phosphorylation accounts for about 6% of the total protein phosphorylation in eukaryotic cells. The knowledge about eukaryotic PHPT (protein histidine phosphatase) is still very limited. To date, only one vertebrate PHPT has been discovered, and two crystal structures of human PHPT1 have been solved. PHPT1 / PHP14 can dephosphorylate a variety of proteins (e.g. ATP-citrate lyase and the beta-subunit of G proteins). A putative active site has been identified by its electrostatic character, ion binding, and conserved protein residues.ied, recombinant Human PHPT1 (rh PHPT1; Catalog#12473-H07E; Q9NRX4-1; Ala2-Tyr125).
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