- ￥3000 - 3999
- Abbiotec
- 美国
- 254287
- 2025年07月16日
- E, WB, IF
- Chicken
- H, M, R
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within human SIRT1.
- 亚型：
Chicken Ig
- 形态：
Each vial contains 0.1 ml IgY in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆
- 标记物：
见下方详细说明
- 适应物种：
H, M, R
- 宿主：
Chicken
- 应用范围：
E, WB, IF
- 浓度：
见详细说明信息
- 靶点：
SIRT1
- 抗体英文名：
SIRT1 Antibody
- 抗体名：
SIRT1 Antibody
- 规格：
0.1 mg
SIRT1 Antibody产品详细介绍：
| 产品名称： | SIRT1 Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 254287 |
| 规格： | 0.1 mg |
| 产品描述： | The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically via lysine residue. |
| 克隆类型： | Chicken Polyclonal Antibody |
| 亚型： | Chicken Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within human SIRT1. |
| 适用物种： | H, M, R |
| 应用范围： | E, WB, IF |
| 应用说明： | E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:100-1:500 |
| 别名： | SIRT1; Sirtuin; NAD-dependent deacetylase sirtuin-1; SIR2L1; hSIR2; hSIRT1 |
| 形态： | Each vial contains 0.1 ml IgY in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验Methods to Investigate the Role of SIRT1 in Endothelial Senescence
Sirtuins are a family of proteins with NAD+ -dependent deacetylase or mono-ADP-ribosyltransferase activity. SIRT1, the mammalian ortholog most closely related to Sir2 (the first gene of this family discovered in yeast), exhibits anti
SILAC-Based Quantification of Sirt1-Responsive Lysine Acetylome
, in combination with affinity enrichment of acetyllysine peptides and mass spectrometry, to study the dynamic changes of the Lysine acetylome in response to Sirt1. The method should be applicable to quantify changes to other post translational modifications
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
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