GLUR3/GRIA 3 Antibody

GLUR3/GRIA 3 Antibody

Cat#：PL0304396

Isotype:Rabbit Polyclonal IgG

Immunogen：Peptide derived from human GLUR3.

Purification: Immunogen affinity purified

Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：

L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS, acting through both ligand gated ion channels (ionotropic receptors) and G-protein coupled (metabotropic) receptors. As such the glutamate receptors play a vital role in the mediation of excitatory synaptic transmission. The ionotropic glutamate receptors are multimeric assemblies of four or five subunits, and are subdivided into three groups (AMPA, NMDA and Kainate receptors) based on their pharmacology structural similarities Glutamate Receptor 3 is a ionotropic, AMPA-selective, membrane bound protein widely distributed in the CNS. Predominant expression is seen in the neuronal cells of the cerebral cortex, dentate gyrus, and glial cells throughout brain regions. AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. Glutamate Receptor 3 exists in 2 named isoforms - Flip and Flop, produced by alternative splicing.

Specificity Reaction：Hu, Mo, Rat, Dog, Pig, Cow, Hor,

Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500

Storage ：

Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

This product for research use only, not for use in humans, therapeutic or diagnostic procedures.

PLlabs公司可供应相应抗体的生物素、辣根过氧化物酶、荧光素（FITC、PE、 CY3、 CY5、 CY7、 PE- CY3/5/7)标记抗体，欢迎大家咨询订购。