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- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
LCZ696
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
936623-90-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1633.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1550.0 |
| 规格： | 50 mg | 产品价格： | ￥3980.0 |
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Sacubitril/Valsartan
CAS No. : 936623-90-4
MCE 国际站：Sacubitril/Valsartan
产品活性：Sacubitril/Valsartan (LCZ696) 是由 Valsartan (an ARB) 和 Sacubitril (AHU377) 组成，摩尔比为 1:1，是一种首创的，口服有效的血管紧张素受体-脑啡肽酶 (ARN) 双抑制剂，用于研究高血压和心力衰竭。Sacubitril/Valsartan 可通过抑制炎症、氧化应激和细胞凋亡来改善糖尿性心肌病。
研究领域：GPCR/G Protein | Metabolic Enzyme/Protease | Apoptosis
作用靶点：Angiotensin Receptor | Neprilysin | Apoptosis
In Vitro: Sacubitril/Valsartan (LCZ696; 1-30 µM; 0.5 hours) inhibits HG-treated H9C2 cells apoptosis in an experimental model of Diabetic cardiomyopathy (DCM).
Sacubitril/Valsartan (1-30 µM; 0.5 hours) increases the expression level of cleaved caspase-3 and the ratio of Bax/Bcl-2 in HG-treated H9C2 cells.
In Vivo: Sacubitril/Valsartan (LCZ696; perorally; 68 mg/kg for 4 weeks) significantly exhibits small weights and reduces interstitial fibrosis both in the noninfarct zone and peri-infarct zone.
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