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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
ATN-161 TFA salt
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
904763-27-5
- 规格：
2 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 2 mg | 产品价格： | ￥800.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1600.0 |
| 规格： | 50 mg | 产品价格： | ￥4800.0 |
| 规格： | 100 mg | 产品价格： | ￥7700.0 |
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ATN-161 trifluoroacetate salt
CAS No. : 904763-27-5
MCE 国际站：ATN-161 trifluoroacetate salt
产品活性：ATN-161 trifluoroacetate salt 是一种新型 integrin α5β1 拮抗剂，在肝转移模型小鼠模型中，抑制血管生成。
研究领域：Cytoskeleton
作用靶点：Integrin
In Vitro: The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p<0.01). In addition, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells (p<0.03), whereas single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time compared to control (p<0.03). ATN-161 inhibites VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P<0.001 vs. VEGF group).
In Vivo: The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564.
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(Bonnerot et al 1987), or by using antibodies to detect both ß-gal and the cellular antigen, one can overcome these problems. If nitroblue tetrazolium (NBT) salt is added to the X-gal reaction in place of iron, a purple precipitate will result
, an Arabidopsis drought and salt tolerance gene. Proc Natl Acad Sci USA 104: 15270-5. 2.Leyser H.M., Lincoln C.A., Timpte C., et al. (1993) Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1. Nature 364: 161
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(e.g., FuGENE 6 from Roche) Hanks' Balanced Salt Solution (HBSS), without Ca2+ and Mg2+ (e.g., Cellgro), but supplemented with 1 mM Ca2+ on the day of the imaging experiment
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