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- 2025年07月12日
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10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥678.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥385.0 |
| 规格： | 10 mg | 产品价格： | ￥616.0 |
| 规格： | 50 mg | 产品价格： | ￥2376.0 |
| 规格： | 100 mg | 产品价格： | ￥3990.0 |
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H-89 dihydrochloride
CAS No. : 130964-39-5
MCE 国际站：H-89 dihydrochloride
产品活性：H-89 dihydrochloride 是一种有效、选择性的 cAMP 依赖性蛋白激酶A (PKA) 抑制剂，IC50 值为 48 nM。也可轻微抑制 PKG，PKC，酪蛋白激酶活性。
研究领域：Stem Cell/Wnt | Autophagy
In Vitro: H-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca2+ uptake by the SR and affectes the Ca2+-sensitivity of the contractile apparatus in rat skinned fibres.
In Vivo: H-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.
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