【AMBP】重组人alpha-1微球蛋白,Recombina

【AMBP】重组人alpha-1微球蛋白，Recombinant Human Alpha-1 Microglobulin，AMBP

产品名称：【AMBP】重组人alpha-1微球蛋白-Recombinant Human Alpha-1 Microglobulin

产品货号：PRO-957

产品规格：10ug///1mg///2ug

来源宿主：大肠杆菌中重组表达

保存建议：【AMBP】重组人alpha-1微球蛋白-Recombinant Human Alpha-1 Microglobulin重组人alpha-1微球蛋白产品在4℃保存请2 - 4周内将使用；-20℃可长期保存.产品若长期保存，建议添加载体蛋白（0.1% HSA或BSA）.避免反复冻融.

背景资料：Alpha 1-microglobulin （A1M） is a lipocalin superfamily member （kernal lipocalins）. A1M is a low molecular weight protein component of plasma. A1M is distributed in plasma and extravascular compartments of all organs. Alpha-1 Microglobulin is found in mammals， birds， amphibians and fish. The primary sites of A1M synthesis are the liver and the kidney. Around the opening of the lipocalin pocket three lysyl residues are situated； those residues carry yellow-brown modification derived from the binding and degradation of heme and kynurenin （a tryptophan metabolite）. A1-Microglobulin’s reductase and dehydrogenase have broad biological substrate specificity properties due to its’ free cysteine side-chain which is located in a flexible loop. Alpha-1-microglobulin is glycosylated by three separate carbohydrate chains: two complex carbohydrates which are N-linked to asparagines at residues 17 and 96， and the other simple carbohydrate which is O-linked to threonine at position 5. The carbohydrates comprise 22% of the total molecular mass of the protein. The glycosylation varies between species. A1M exists in two forms- a free form and complexed to other macromolecules: in humans- complexed to immunoglobulin A （IgA）， in rat- complexed to alpha-1-inhibitor-3. Free A1M is exceptionally heterogeneous in charge （therefore also known as protein HC）， and is found tightly linked to a chromophore. The free Alpha-1-microglobulin is a monomeric protein composed of one 188 residue polypeptide and contains three cysteines， two of which （residues 75 and 173） form a conserved intra-molecular disulphide link. The chromophoric group is covalently bound to the free cysteine residue at position 34. A1M binds retinol as a major ligand， but this is probably distinct from its covalent chromophore. Half of all human plasma A1M （approximately 0.03mg/ml） forms a 1:1 complex with about 5% of plasma immunoglobulin A. The resulting macromolecular complexes’ molecular weight is 200000， and a plasma concentration of 0.3mg/ml. The complex can exhibit both antibody activity and affect many of the biological actions of free Alpha-1-microglobulin. Alpha-1-microglobulin was first discovered in pathological human urine.It was suggested that A1M might be involved in tissue defense against reactive oxygen species， oxidation by heme and kynurenin. Evidence also suggests that A1M functions in the regulation of the immune system. Other functions include: inhibition of stimulation of cultured lymphocytes by protein antigens； induction of cell division of lymphocytes， a mitogenic effect that can either be enhanced or inhibited by the action of other plasma components； inhibition of neutrophil granulocyte migration in vitro； and inhibition of chemotaxis.

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ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

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