【TREM1】重组人髓样细胞触发性受体-1,Recombin

【TREM1】重组人髓样细胞触发性受体-1，Recombinant Human Triggering Receptor Expressed on Myeloid Cells 1，TREM1

产品名称：【TREM1】重组人髓样细胞触发性受体-1-Recombinant Human Triggering Receptor Expressed on Myeloid Cells 1

产品货号：PRO-457

产品规格：10ug///1mg///2ug

来源宿主：大肠杆菌中重组表达

保存建议：【TREM1】重组人髓样细胞触发性受体-1-Recombinant Human Triggering Receptor Expressed on Myeloid Cells 1 Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Please avoid freeze thaw cycles.

背景资料：TREM1 is a transmembrane receptor protein that is involved in monocytic activation and in the inflammatory response. TREM1 is expressed on the surface of neutrophils， mature monocytes and macrophages. TREM1 stimulates neutrophil and monocyte-mediated inflammatory responses. TREM1 also triggers the release of pro-inflammatory chemokines and cytokines， as well as increased surface expression of cell activation markers. Furthermore， TREM1 is an amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a fundamental mediator of septic shock. The expression of the soluble form of TREM1 increases during sepsis and can consequently be used as a biological marker for septic shock. TREM1 is strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Increased TREM1 expression on monocytes is related to both infectious and noninfectious inflammatory processes.TREM1 is vastly expressed in adult liver， lung and spleen than in corresponding fetal tissue. TREM1 is also expressed in the lymph node， placenta， spinal cord and heart tissues. TREM1 expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. TREM1 is expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes.

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